As is well known, we are far from a full canon story with the various stories having bits and pieces and we lack significant characters needed for it such as Umbrella and Marie herself. One thing we know is that it would not just be one person who could fight Marie to be able to bring her down in a true story. The question then turns to, who could we expect/predict to be the ones "fated" to face off against the skullgirl in the fights that lead to the demise. Last that I saw of this information, it was given somewhat vaguely that it would take 3-4 characters. Here is my opinion on the matter: Peacock is the character with the most personal investment when it comes to Marie and has potentially one of the strongest arsenals in the Avery system. Painwheel in essentially a literal sense was created explicitly to fight off Marie. Once again, a powerhouse of two synthetic parasites and some of the most aggressive drives for fighting Marie. Squiggly, the only DLC character that was part of the Original 8 of the earliest drafts of Skullgirls (back when it was magical), has her more connected synergy with Leviathan than the semi-parasitic (no pun intended) relationship between Samson and the amnesiac Samson. Being an undead arisen by Marie and the ties to her mother, the skullgirl from 14 years ago, it seems to add up in her favor. Lastly... I see it being Umbrella. Sub-consciously drawn to the Skullheart due to the association to her mother, Umbrella clearly has stronger direct ties to the relic than anyone else of the cast. Combine this with a weapon on par of her sister, being the only missing member of the Original 8, and being stressed in her importance to a canon story... it seems like a perfect storm that we need an Umbrella for. But in all seriousness, my theory is that in a canon story in which it requires 4 people fighting Marie to take her down, that it would come to be Peacock, Painwheel, Squiggly, and Umbrella. Any other thoughts out there?