This may be irrelevant now that the game has been out for so long but I just got into it, and have some things to add to the Double-Macbeth reference. In Act 4 Scene 1 of Macbeth the three witches indeed say "Double, double toil and trouble" in between other 'verses' to their chant. The whole character of double seems to be a reference to this scene, or at least has many loose connections. First of all their is an achievement or trophy named "Toil and trouble" which is an obvious and direct link to the scene. In the 'verses' that the witches chant in Macbeth, they talk about all the things that they are putting into their cauldron. The ingredients include entrails, different animals and poisons, eye of newt, part of a still-born child born from a prostitute and liver from a blaspheming Jew. It seems plausible that all of these things (I didn't name them all, just the ones I found most interesting) add up to the amalgamation that Double is. Double has different looking entrails and eyes and different strange parts to her, all of which are bubbling and boiling as if they had just come out of a cauldron. Her animations and art resemble the sum of lots of the stuff that the witches talked about in Macbeth. This also works with the way that the character fights, she changes shape into many of the other Skullgirls characters when fighting which creates a good parallel with the ingredients of the cauldron. Many seemingly unrelated parts coming together to form this strange creature or concoction. I know that in the lore there is a fair chance that Double was 'created' which further supports my claims, but I don't know a whole lot about the lore of this game yet so there may be conflicting or even further supporting information.
I don't think that I've ever heard of a Jewish nun, so that might not connect to the character in Skullgirls exactly, but you could argue that the liver of the blaspheming Jew might contribute to her obviously evil transformation. There is another famous line from the witches in Macbeth that is in Act 1 Scene 1 "Fair is foul and foul is fair" which I think also links to this 'theory' (for lack of a better word). That line may relate to the two sides of Double's character. The "fair" side of her being the Nun that she transforms into as a disguise, and the foul side obviously being her true form, the creature that she is. The fact that Double transforms into an innocent nun to disguise herself also fits into the idea that things are not always what they seem, which is one of the main themes of Macbeth as a whole. An example of that theme in Macbeth (for all who care) is Macbeth being seen as this heroic, loyal trustworthy soldier when really he plans to Kill the king and take over the throne.
I know I may be overthinking this... a lot. But even if none of this was by design, there is an obvious link to the play in this character, and it is interesting and fun (for me at least) to go through all of the possible connections especially since I am currently studying Macbeth. If anyone has anything to add to this or anything to argue please make an account and let me know because again, it's very interesting!
EDIT: I just realized that this is almost exactly 1 year since the last post on this thread.