Story begins 14 years ago, with Double delivering her special gift of the Skullheart to the Contiellos. Selene, immediately sensing the danger of having such a bloodstained omen nearby, tries to talk to her husband, Roberto. However, Roberto has a toast and a surprise for her: the first live (lol) performance of Seinna! Just as she finishes her song ends Selene finally gets a moment to talk...or she would have if it wasnt for the sound of Gunfire. Black Dahalia and her goons show up demanding the Skullheart. When Selene feigns ignorance, Seinna is claimed as a hostage. Selene then admits she had received the heart and was prepared to hand it over. Dahalia taunts the family name, to which poor Seinna takes offense to. Dahalia is unamused, and shoots her at point blank. Selene, overcome with grief, wishes to save her family. Roberto with his dying breath, commands leviathan to go to Sienna and protect her from becoming a mindless minion. They part ways, and Selene as the Skullgirl begins her counterattack...
Squiggly eventually comes too...dead as a door nail. Leviathan fills her in on the details but notes some oddities. Zombies are usually under complete control of their masters, and parasites should be much weaker without a living host. Yet both of them are fine...for the most part. The duo decides to confront the skullgirl while trying to stay away from the Medicis. Sienna requests to be called Squiggly for now on, and the two head out.
Its not long before Squiggly finds her parents confronting Lorenzo and Dahalia. Squiggly tries to talk some sense into them, but fails, and almost ends up becoming a minion herself due to the hearts influence. She is able to stay her ground, but she doesnt have the heart to off them herself. Out of the blue, reinforcements arrive! D.Violet, Big Band, Panzerfaust, and Annie all arrive on the scene. Selene and her husband retreat, as do Lorenzo and Dahalia to the shadows.
Squiggly and the group discuss their next plan of action, but leviathan is less than thrilled about working with anyone who belongs with the Renoir faction. Annie noticed that Squiggly's parents didnt go all out on her, and suggests to use Squiggly as a lure so they can take them out. Leviathan is HIGH KEY MAD about this but a report comes in about the skullgirl minions hunting down citizens to swell up her army. In a densely populated city, they had to act immediately. Squiggly volunteers, and leviathan solemnly agrees to help her. With their combined might, squiggly and the gang defeat Roberto, and soon after Selene.
In her final moments of lucidity, Selene says shes proud of her daughter and fades away. Without the energy of the Skullgirl, squiggly and leviathan crumple to the ground, returning to the sweet sleep of death. Panzerfaust and Big Band kept squiggly a secret from the Labs, lest people like Brain Drain experiment on their bodies extensively. Lorenzo eventually claims squigglys body and holds their mockery funeral, and the two lie there until Marie rises.